BETTA-PROPARGILOKSINAFTALINNI 2-BROM-4-NITROFENILAZID BILAN HALQALANISH REAKSIYASINI O‘RGANISH

Anvar Shomurodov; Boburbek Ismailov; Abdulhamid Maxsumov; Shoyunus Obidov

doi:10.66960/aq56nz37

Authors

Anvar Shomurodov Author
Boburbek Ismailov Author
Abdulhamid Maxsumov Author
Shoyunus Obidov Author

DOI:

https://doi.org/10.66960/aq56nz37

Keywords:

2-propargiloksinaftalin, arilazid, terminal alkin, azid-alkin siklobirikish, dixlormetan, 1H -1,2,3-triazollar, 1-(2-brom-4-nitrofenil)-4-((naftalin-2-iloksi)metil)-1H-1,2,3-triazol.

Abstract

Beta-naftolni propargil bromid bilan alkillab tegishli 2-propargiloksinaftalin sintez qilingan. 2-brom-4-nitroanilindan diazotirlab natriy azid ta’sir ettirish orqali esa 2-brom-4-nitrofenilazid olingan. Sintez qilib olingan propargil efir va aromatik azidning o‘zaro siklobirikish reaksiyasi o‘rganilgan. Halqalanish natijasida 1H-1,2,3-triazolning 1,4-izomer hosilasi – 1-(2-brom-4-nitrofenil)-4-((naftalin-2-iloksi)metil)-1H-1,2,3-triazol hosil bo‘lishi aniqlangan. Reaksiyaga katalizator, harorat va erituvchilar ta’siri o‘rganilgan. Sintez qilingan moddalarning tuzilishi IQ, YaMR spektrlari orqali tasdiqlangan.

Author Biographies

Anvar Shomurodov

Kimyo fanlari bo‘yicha falsafa doktori (PhD), Sho‘rtan gaz-kimyo majmuasi MCHJ, O‘zbekiston
Boburbek Ismailov

Texnika fanlari bo‘yicha falsafa doktori (PhD), dotsent, Toshkent kimyo-texnologiya instituti Neft va gazni qayta ishlash kimyoviy texnologiyasi kafedrasi dotsenti, Toshkent shahri, O‘zbekiston
Abdulhamid Maxsumov

Kimyo fanlari doktori, professor, Toshkent kimyo-texnologiya instituti Neft va gazni qayta ishlash kimyoviy texnologiyasi kafedrasi professori, Toshkent shahri, O‘zbekiston
Shoyunus Obidov

Texnika fanlari bo‘yicha falsafa doktori (PhD), Toshkent kimyo-texnologiya instituti Neft va gazni qayta ishlash kimyoviy texnologiyasi kafedrasi v.b. dotsenti, Toshkent shahri, O‘zbekiston

References

Assis S. P. D. O., Silva M. T. D., de Oliveira R. N., Lima V. L. D. M. // The Scientific World Journal, 2012(1), 925925. P. 1-7. DOI: https://doi.org/10.1100/2012/925925

Shafi S., Alam M. M., Mulakayala N., Mulakayala C., Vanaja G., Kalle A. M., Alam M. S. // European journal of medicinal chemistry, 49, 2012, 324-333 p. DOI: https://doi.org/10.1016/j.ejmech.2012.01.032

S.G.Usmonova. Orto-, para-propargiloksibenzaldegidlar asosida 1,2,3-triazol hosilalari sintezi va ularning kimyoviy xossalarini o‘rganish.// Dissertatsiya.2023 , 83-89 b.

Saeedi M., Mohammadi-Khanaposhtani M., Pourrabia P., Razzaghi N., Ghadimi R., Imanparast S., Akbarzadeh T. // Bioorganic chemistry, 83, 2019, 161-169 p. DOI: https://doi.org/10.1016/j.bioorg.2018.10.023

Aufort M., Herscovici J., Bouhours P., Moreau N., Girard C. // Bioorganic Medicinal chemistry letters, 18(3), 2008, 1195-1198 p. DOI: https://doi.org/10.1016/j.bmcl.2007.11.111

Maxsumov A.G., Madixanov N., Abdugafurov I.A. // Jurn.org.xim.-1987. -T. 23,-№ 9. - S. 1986-1990.

Madixanov N., Juraev A.Dj., Maxsumov A.G., Abdugafurov I.A., Zokirov U.B. Patent. Yallig‘lanishga qarshi«Fentriazolin» surtma dorisi. -UzR. IAP. -№ 01960. -2000.

Djafri Ayada, Derdour Aicha // Monography. University of Annee. 18.03.2014. P. 164 DOI: https://doi.org/10.1055/s-0034-1373699

Asgari M. S., Mohammadi-Khanaposhtani M., Sharafi Z., Faramarzi M. A., Rastegar H., Nasli Esfahani E., Larijani B. // Molecular Diversity, 25, 2021, 877-888 p. DOI: https://doi.org/10.1007/s11030-020-10072-8